Aspects of Human Gene Therapy :: Science Biology Genetic Essays

Aspects of Human Gene Therapy Introduction The prospect of human gene therapy was first realized in 1971 when the first recombinant DNA experiments were planned. Gene therapy can be simply viewed as inserting bits of foreign DNA into a patient’s tissue in hopes of evoking a biologic response that will effectively eliminate the targeted disease. Major advances in recombinant DNA technology have occurred over the last 20 years so that now gene therapy is becoming a reality. Gene therapeutic techniques have recently been attempted to treat patients with the genetic diseases severe combined immune deficiency (SCID), cystic fibrosis, and Duchenne’s muscular dystrophy (Donegan, 1995). The optimist foresees a time when a patient will simply receive a snippet of DNA and go home cured. There are many ethical and scientific hurdles that must first be crossed for such a dream to become reality. The technology has advanced so rapidly that many ethical questions weren’t originally addressed and accordingly are now bec oming the center of attention regarding human genetic research. Furthermore, scientists must find a way to outwit the body’s immune system which is primed to fight any foreign material such as inserted genes. There are also difficulties in getting the targeted cells to open up their molecular locks to allow the foreign genes inside. Gene therapy, like other medical advances before it, will have numerous failures before reaching its full potential. It will be important for the public, press, and medical industry to be patient in waiting for the dream of gene therapy to become a reality. Technological Aspects of Gene Therapy The underlying principle of gene therapy is the transfer of genetic material to specific cells of a patient in an effort to initiate a biological response to fight or eliminate a disease. There are two possible types of target cells, somatic cells that are non-reproducing, or reproducing germ-line cells. If germ-line cells are permanently altered, all future generations would be effected. Most of the current human genetic research involves somatic cells since the ethical ramifications of germ-line cell modification is still being debated. Some scientists have expressed concerns that even altered somatic cell genes could find their way to reproducing, germ-line cells (Donegan, 1995). Accordingly, regulations are strict in regards to somatic cell gene modification techniques so that this gene migration will not occur. Transfer of genes to target cells is usually accomplished by some sort of vector such as retroviruses, adenoviruses, or liposomes (Mulligan, 1993; Crystal, 1995).

A Tale of Two Cities Humor Essay

Humor in A Tale of Two Cities This novel is filled with humor but one scene that catches attention as humorous is in Chapter one of the Second Book, Jerry Cruncher is the most comical character in the book and in this particular scene he yells at his wife for praying against her. This is comical because it is so absurd especially the way Dickens depicts it. Mr.Cruncher wa kes up to find his wife praying and yells twice that she is â€Å"at it agin† (Dickens 56), so he continues to throw a muddy boot at her. Mrs.Cruncher only responds after he addresses her again, she explains that she was not praying against him but for him. This entire scene is utterly ridiculous because she was just being a peaceful wife but her husband assumes she is praying for him to be unsuccessful. He has no evidence to back up his accusation yet continues to believe it. This scene also display terrible sexism on the part of Jerry Cruncher. Humor in A Tale of Two Cities This novel is filled with humor but one scene that catches attention as humorous is in Chapter one of the Second Book, Jerry Cruncher is the most comical character in the book and in this particular scene he yells at his wife for praying against her. This is comical because it is so absurd especially the way Dickens depicts it. Mr.Cruncher wa kes up to find his wife praying and yells twice that she is â€Å"at it agin† (Dickens 56), so he continues to throw a muddy boot at her. Mrs.Cruncher only responds after he addresses her again, she explains that she was not praying against him but for him. This entire scene is utterly ridiculous because she was just being a peaceful wife but her husband assumes she is praying for him to be unsuccessful. He has no evidence to back up his accusation yet continues to believe it. This scene also display terrible sexism on the part of Jerry Cruncher. Humor in A Tale of Two Cities This novel is filled with humor but one scene that catches attention as humorous is in Chapter one of the Second Book, Jerry Cruncher is the most comical character in the book and in this particular scene he yells at his  wife for praying against her. T his is comical because it is so absurd especially the way Dickens depicts it. Mr.Cruncher wa kes up to find his wife praying and yells twice that she is â€Å"at it agin† (Dickens 56), so he continues to throw a muddy boot at her. Mrs.Cruncher only responds after he addresses her again, she explains that she was not praying against him but for him. This entire scene is utterly ridiculous because she was just being a peaceful wife but her husband assumes she is praying for him to be unsuccessful. He has no evidence to back up his accusation yet continues to believe it. This scene also display terrible sexism on the part of Jerry Cruncher.

Definition and Examples of Argumentum Ad Misericordiam

Ad misericordiam is an argument based on a strong appeal to the emotions. Also known as  argumentum ad misericordiam  or  appeal to pity or misery. When an appeal to sympathy or pity is highly exaggerated or irrelevant to the issue at hand, ​ad misericordiam is regarded as a logical fallacy.  The first mention of  ad misericordiam  as a fallacy was in an article in the  Edinburgh Review  in 1824. Ronald Munson points out that [n]ot all mention of factors which appeal to our sympathies is irrelevant [to an argument], and the trick is to distinguish legitimate appeals from spurious ones (The Way of Words). From the Latin, appeal to pity   Examples and Observations Your Honor, my incarceration is cruel and unusual punishment. First, my prison-issued shower sandals are grossly undersized. Secondly, the prison book club consists mainly of prisoners who club me with books.(Sideshow Bob in Day of the Jackanapes. The Simpsons, 2001)This appeal to our emotions need not be fallacious or faulty. A writer, having argued several points logically, may make an emotional appeal for extra support. . . .When an argument is based solely on the exploitation of the readers pity, however, the issue gets lost. Theres an old joke about a man who murdered his parents and appealed to the court for leniency because he was an orphan. Its funny because it ludicrously illustrates how pity has nothing to do with murder. Lets take a more realistic example. If you were a lawyer whose client was charged with bank embezzlement, you would not get very far basing your defense solely on the fact that the defendant was abused as a child. Yes, you may touch the hearts of the juror s, even move them to pity. Yet that would not exonerate your client. The abuse the defendant suffered as a child, as woeful as it is, has nothing to do with his or her crime as an adult. Any intelligent prosecutor would point out the attempt to manipulate the court with a sob story while distracting it from more important factors such as justice.(Gary Goshgarian, et al., An Argument Rhetoric and Reader. Addison-Wesley, 2003) Germaine Greer on Hillary Clintons Tears Watching Hillary Clinton pretending to get teary-eyed is enough to make me give up shedding tears altogether. The currency, you might say, has become devalued. . .   Hillarys feeble display of emotion, while answering questions from voters in a cafe in Portsmouth, New Hampshire, on Monday, is supposed to have done her campaign the world of good. If it has, its because people have wished a tear into her stony reptilian eye, not because there actually was one. What caused her to get all mooshy was her mention of her own love of her country. Patriotism has once more proved a valuable last refuge for a scoundrel. Hillarys clipped diction did not falter; all she had to do was take the steel edge off her voice and our imaginations did the rest. Hillary was human after all. Fear and loathing fled New Hampshire, Hillary scored against the run of play, and all it took was the suspicion of a tear. Or so they say. Can the moral of the story be: when youre up against it, dont fight back, just cry? As if too many women dont already use tears as a power-tool. Over the years Ive had to deal with more than one manipulative student who produced tears instead of w ork; my standard response was to say, Dont you dare cry. Im the one who should be crying. Its my time and effort thats being wasted. Lets hope Hillarys crocodile effort doesnt encourage more women to use tears to get their way.(Germaine Greer, For Crying Out Loud! The Guardian, January  10, 2008) An Argument That Raises a Warning Signal ​​Plenty of evidence has been presented that the ad misericordiam is both a powerful and deceptively misleading tactic of argumentation well worth careful study and evaluation. On the other hand, our treatment also suggests that it is misleading, in various ways, to think of the appeal to pity simply as a fallacious argument move. The problem is not that appeal to pity is inherently irrational or fallacious. The problem is that such an appeal can have such a powerful impact that it easily gets out of hand, carrying a weight of presumption far beyond what the context of dialogue merits and distracting a respondent from more relevant and important considerations.While ad misericordiam arguments are fallacious in some cases, it is better to think of the argumentum ad misericordiam not as a fallacy (at least per se, or even most importantly) but as a kind of argument that automatically raises a warning signal: Look out, you could get in trouble with this kind of argument if you are not very careful!(Douglas N. Walton, The Place of Emotion in Argument. Penn State Press, 1992) The Lighter Side of Ad Misericordiam: The Job Applicant Seated under the oak the next evening I said, Our first fallacy tonight is called Ad Misericordiam.[Polly] quivered with delight.Listen closely, I said. A man applies for a job. When the boss asks him what his qualifications are, he replies that he has a wife and six children at home, the wife is a helpless cripple, the children have nothing to eat, no clothes to wear, no shoes on their feet, there are no beds in the house, no coal in the cellar, and winter is coming.A tear rolled down each of Polly’s pink cheeks. Oh, this is awful, awful, she sobbed.Yes, it’s awful, I agreed, but it’s no argument. The man never answered the boss’s question about his qualifications. Instead he appealed to the boss’s sympathy. He committed the fallacy of Ad Misericordiam. Do you understand?Have you got a handkerchief? she blubbered.I handed her a handkerchief and tried to keep from screaming while she wiped her eyes.(Max Shulman, The Many Loves of Dobie Gillis. Doubl eday, 1951)